Estreva 0,1%
- [i] 7 pumps of 0,2 g twice daily = 2,8 g/day → 2,8 mg E2/day transdermal
- [“] Absorption: ~10–20% → ~0.3–0.6 mg/day
- [“] Systemic E2: ~2–4 mg/week
- [*] Bioavailable E2: ~0.3–0.6 mg/day
- [p] easy to adjust dosage
- [p] steady transdermal delivery
- [c] variable absorption
- [c] twice daily application
- [c] skin contact to others after applying
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EV (Estradiolvalerate) 20 mg/mL
- [i] 0,25 mL once weekly subcutaneous → 5 mg E2/week subcutaneous
- [“] Absorption: Full dose (injected depot)
- [“] Systemic E2: ~3.5–4.5 mg/week
- [*] Bioavailable E2: ~0.5–0.65 mg/day (avg)
- ~0.8–1.0 mg/day (day after injection)
- ~0.4–0.5 mg/day (day before next dose)
- [p] stable E2 levels
- [p] no daily routine
- [p] consistent absorption
- [c] less flexible to adjust dose
- [c] injection required